Video Experimental Relacionado
Updated: Jul 15, 2026
16:07
Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Asociación de TNF2, un polimorfismo promotor de TNF-alfa, con susceptibilidad y mortalidad por shock séptico: un
1Intensive Care Unit, Cochin Port-Royal University Hospital, Paris, France.
JAMA
|August 18, 1999
Resumen
El alelo TNF2 está relacionado con una mayor susceptibilidad al shock séptico y un mayor riesgo de muerte por esta infección grave. Este factor genético juega un papel importante en los resultados de los pacientes.
Área de la Ciencia:
- Inmunogenética La inmunogenética.
- Medicina de cuidados críticos Medicina de cuidados críticos.
- Biología Molecular Biología Molecular
Sus antecedentes:
- El factor de necrosis tumoral alfa (TNF-alfa) es una citocina clave en la patogénesis del shock séptico.
- El polimorfismo de TNF2 en el promotor del gen TNF-alfa se asocia con un aumento de la producción de TNF-alfa y peores resultados en las infecciones.
Objetivo del estudio:
- Para determinar la frecuencia del alelo TNF2 en pacientes con shock séptico.
- Evaluar la asociación entre el alelo TNF2 y la ocurrencia de shock séptico y la mortalidad.
Principales métodos:
- Se realizó un estudio multicéntrico de casos y controles en el que participaron 89 pacientes con shock séptico y 87 controles sanos.
- Se compararon las frecuencias del alelo TNF2 entre los grupos y se midieron las concentraciones de TNF-alfa.
- Análisis de regresión logística controlada por edad y puntaje fisiológico agudo simplificado (SAPS II).
Principales resultados:
- Los pacientes con shock séptico tenían una mayor frecuencia del alelo TNF2 (39%) en comparación con los controles (18%).
- El alelo TNF2 fue más prevalente en los no sobrevivientes (52%) que en los sobrevivientes (24%) del shock séptico.
- Los pacientes con el alelo TNF2 tenían un aumento de 3,7 veces el riesgo de muerte, independientemente de la puntuación SAPS II.
Conclusiones:
- El alelo TNF2 está fuertemente asociado con la susceptibilidad a desarrollar shock séptico.
- El alelo TNF2 es un factor de riesgo significativo para la mortalidad en pacientes con shock séptico.
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