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Depresión a largo plazo en las interneuronas del hipocampo: requisito conjunto para eventos pre y postsinápticos
F Laezza1, J J Doherty, R Dingledine
1Neuroscience Graduate Program, Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Science (New York, N.Y.)
|August 28, 1999
Resumen
La depresión a largo plazo (LTD) ocurre en las interneuronas del hipocampo, desafiando suposiciones anteriores. Esta plasticidad sináptica se basa en la afluencia de calcio a través de los receptores AMPA y los receptores presinápticos similares a mGluR7.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La plasticidad sináptica.
- Las interneuronas del hipocampo
Sus antecedentes:
- La depresión a largo plazo (LTD) es una forma clave de plasticidad sináptica en las neuronas principales.
- La aparición de LTD en las interneuronas sigue siendo un tema de debate.
Objetivo del estudio:
- Para investigar si las interneuronas hipocampales CA3 exhiben LTD.
- Para dilucidar los mecanismos moleculares subyacentes LTD en estas interneuronas.
Principales métodos:
- Estimulación tetánica de las entradas excitatorias CA3 a las interneuronas.
- Registros electrofisiológicos para evaluar la fuerza sináptica.
- Manipulación farmacológica para investigar la participación de los receptores.
Principales resultados:
- Las interneuronas hipocampales CA3 que expresan receptores AMPA Ca2+-permeables se han demostrado LTD.
- LTD fue independiente de los receptores de N-metil-D-aspartato (NMDA).
- LTD requería un influjo postsináptico de Ca2+ a través de los receptores AMPA y una activación presináptica del receptor mGluR7-like.
Conclusiones:
- Las interneuronas son capaces de sufrir cambios plásticos en la fuerza sináptica.
- La plasticidad sináptica en las interneuronas implica la acción coordinada de los receptores pre y postsinápticos de glutamato.
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