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Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
Published on: May 16, 2019
La suplementación con zinc y el crecimiento óseo en niñas en la pubertad
Lancet (London, England)
|August 28, 1999
Resumen
Este estudio encontró que la suplementación de zinc en niñas peripubertas no afectó a los marcadores de crecimiento óseo, a pesar de aumentar los niveles séricos de zinc. La mayoría de los participantes tenían una ingesta insuficiente de zinc en la dieta antes de la intervención.
Área de la Ciencia:
- Nutrición pediátrica para niños.
- Metabolismo de los minerales.
- Desarrollo esquelético Desarrollo esquelético.
Sus antecedentes:
- La ingesta adecuada de zinc es crucial para el crecimiento y el desarrollo durante la pubertad.
- La baja ingesta de zinc en la dieta es común en las poblaciones adolescentes.
- El impacto de la suplementación de zinc en la salud ósea en las niñas peripuberales requiere una investigación adicional.
Objetivo del estudio:
- Para investigar el efecto de la suplementación de zinc en los niveles séricos de zinc y los marcadores de rotación ósea en niñas peripubertas.
- Evaluar si la suplementación de zinc a corto plazo puede influir en los indicadores de desarrollo esquelético en este grupo de edad.
Principales métodos:
- Un ensayo aleatorizado, controlado con placebo, en el que participaron 47 niñas peripubertas.
- Suplementación con 15 mg/día de zinc o placebo durante 6 semanas.
- La medición del zinc sérico, el factor de crecimiento similar a la insulina I y los marcadores bioquímicos de la rotación ósea.
Principales resultados:
- La suplementación con zinc aumentó significativamente los niveles séricos de zinc en comparación con el placebo.
- No se observaron cambios significativos en el factor de crecimiento I similar a la insulina o en los marcadores de rotación ósea.
- La mayoría de los participantes (94%) tenían una ingesta dietética de zinc por debajo del nivel de referencia al inicio.
Conclusiones:
- La suplementación de zinc a corto plazo aumenta efectivamente el zinc sérico en niñas peripubertas con baja ingesta dietética.
- Este nivel de suplementación con zinc no afectó a los indicadores clave del crecimiento óseo o la rotación ósea en esta población.
- Se necesita más investigación para determinar los efectos a largo plazo y la dosis óptima de zinc para la salud ósea pediátrica.
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