Video Experimental Relacionado
Updated: Jul 23, 2026
09:53
Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5
Published on: July 13, 2011
Insuficiencia renal aguda con implicación neurológica en adultos asociados con el aislamiento del virus del sarampión
N S Wairagkar1, B V Gandhi, S M Katrak
1National Institute of Virology, Pune, India. icmrniv@icmrniv.ren.nic.in
Lancet (London, England)
|September 29, 1999
Resumen
El virus del sarampión causó insuficiencia renal aguda y síntomas neurológicos en adultos sin erupción. Este diagnóstico es crucial para los programas de eliminación del sarampión, destacando las presentaciones atípicas.
Área de la Ciencia:
- Virología Virología.
- Neurología Neurología.
- Nefrología Nefrología.
Sus antecedentes:
- Investigó tres casos de adultos con insuficiencia renal aguda con implicación neurológica en Mumbai, India.
- Inicialmente se desconocía la etiología de los síntomas neurológicos y renales.
Objetivo del estudio:
- Para identificar el agente causante de la insuficiencia renal aguda y los síntomas neurológicos en pacientes adultos.
- Para describir los hallazgos clínicos y de laboratorio asociados con esta presentación inusual.
Principales métodos:
- Analizó informes de casos y hallazgos de laboratorio de tres pacientes adultos.
- Prueba de suero y líquido cefalorraquídeo para infecciones virales, incluido el sarampión, utilizando IgM ELISA, aislamiento del virus en cultivos de células Vero y ensayos de inmunofluorescencia.
Principales resultados:
- Los pacientes presentaron fiebre, vómitos, insuficiencia renal, debilidad facial, pérdida auditiva, parálisis y dificultad respiratoria, sin una erupción típica.
- Se observaron niveles elevados de nitrógeno y creatinina de urea en sangre, alto contenido de proteínas y pleocitosis en el líquido cefalorraquídeo, y nefritis intersticial en la biopsia de riñón.
- Se confirmó la infección por el virus del sarampión a través de anticuerpos IgM en el suero y el líquido cefalorraquídeo, y el aislamiento del virus del sarampión de muestras clínicas.
Conclusiones:
- Manifestaciones inusuales confirmadas de insuficiencia renal aguda con implicación neurológica asociada con el virus del sarampión en adultos que se presentan sin erupción.
- Los hallazgos pueden afectar el desarrollo y las estrategias de los programas de eliminación del sarampión a nivel mundial.
Más Videos Relacionados
09:23Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection
Published on: March 9, 2018
08:36The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials
Published on: April 19, 2024
Videos de Conceptos Relacionados
01:28Disorders of the Nervous Tissue
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:19Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
01:19Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...