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El brote de infección por el virus Nipah entre los trabajadores de un matadero en Singapur
1Department of Infectious Diseases, Communicable Disease Centre, Tan Tock Seng Hospital, Singapore. Paton_NIJ@notes.ttsh.gov.sg
Lancet (London, England)
|October 16, 1999
Resumen
La infección por el virus Nipah causó encefalitis y neumonía en trabajadores de un matadero de Singapur. Las imágenes de resonancia magnética revelaron lesiones cerebrales características, y la participación pulmonar era común.
Área de la Ciencia:
- Virología Virología.
- Neurología Neurología.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- En marzo de 1999, se produjo un brote de encefalitis y neumonía en trabajadores de un matadero en Singapur.
- Este estudio describe la presentación clínica y los resultados de la investigación de los individuos afectados.
Objetivo del estudio:
- Describir las características clínicas y los hallazgos diagnósticos de la infección por el virus Nipah.
- Para identificar hallazgos radiológicos característicos asociados con la encefalitis por el virus Nipah.
Principales métodos:
- Revisión sistemática de los datos clínicos y de laboratorio de los pacientes afectados.
- Detección de anticuerpos IgM específicos del virus Nipah en suero mediante ELISA.
- Identificación del ARN del virus Nipah en el líquido cefalorraquídeo (LCR) y muestras de tejido mediante PCR de transcriptasa inversa.
Principales resultados:
- Se confirmó la infección aguda por el virus Nipah en once pacientes; el virus Nipah se identificó en un caso fatal.
- Los síntomas comunes incluyen fiebre, dolor de cabeza y somnolencia; ocho pacientes presentaron encefalitis, tres neumonía atípica.
- La resonancia magnética reveló lesiones focales de la sustancia blanca en pacientes con encefalitis; ocho de los nueve tratados con aciclovir sobrevivieron.
Conclusiones:
- La infección por el virus Nipah es una causa de encefalitis con hallazgos distintos de resonancia magnética.
- La afectación pulmonar es frecuente, y la enfermedad puede manifestarse como neumonía atípica.
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