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Farmacogenómica: traducir la genómica funcional en una terapéutica racional
1Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. williams.evans@stjude.org
Science (New York, N.Y.)
|October 16, 1999
Resumen
Las variaciones genéticas influyen en la forma en que los individuos responden a los medicamentos, afectando tanto a la eficacia como a los efectos secundarios. La farmacogenómica utiliza esta información genética para personalizar la terapia farmacológica para obtener mejores resultados para los pacientes.
Área de la Ciencia:
- La farmacogenómica es la farmacogenómica.
- Genética La genética.
- Metabolismo de las drogas Metabolismo de las drogas
Sus antecedentes:
- Las respuestas individuales a los medicamentos varían significativamente.
- Se sabe que los factores genéticos influyen en la eficacia y toxicidad de los medicamentos.
- Comprender estas influencias genéticas es crucial para una terapia farmacológica efectiva.
Objetivo del estudio:
- Para resaltar el papel de los polimorfismos genéticos en la respuesta a los medicamentos.
- Para enfatizar la contribución de los estudios farmacogenómicos al descubrimiento de fármacos.
- Para subrayar la base científica para la medicina personalizada.
Principales métodos:
- Revisión de los estudios farmacogenómicos.
- Análisis de polimorfismos genéticos en genes relacionados con las drogas.
- Correlación de las variaciones genéticas con la disposición y los efectos de las drogas.
Principales resultados:
- Los polimorfismos genéticos en enzimas, transportadores y receptores afectan la eficacia y toxicidad de los fármacos.
- La investigación farmacogenómica está aclarando la base genética de la respuesta a los fármacos.
- Estos hallazgos apoyan la optimización de la terapia farmacológica basada en la genética individual.
Conclusiones:
- La farmacogenómica proporciona una base científica para adaptar los tratamientos farmacológicos.
- Comprender las variaciones genéticas mejora el descubrimiento y desarrollo de fármacos.
- La medicina personalizada basada en la farmacogenómica mejora los resultados terapéuticos.
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