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Updated: Jul 20, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Regulación de retroalimentación negativa de la señalización de TGF-beta por la oncoproteína SnoN

S L Stroschein1, W Wang, S Zhou

  • 1Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA.

Science (New York, N.Y.)
|October 26, 1999
PubMed
Resumen

La oncoproteína SnoN reprime la señalización del factor de crecimiento transformador-beta (TGF-beta) al interactuar con las proteínas Smad. La estimulación de TGF-beta inicialmente degrada SnoN, permitiendo la activación génica, pero luego aumenta SnoN para terminar la señalización.

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