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Measuring Single-Cell Mitochondrial DNA Copy Number and Heteroplasmy Using Digital Droplet Polymerase Chain Reaction
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Una gran acumulación de mutaciones puntuales dependientes del envejecimiento en la región de control del ADNmt humano
Y Michikawa1, F Mazzucchelli, N Bresolin
1Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
Science (New York, N.Y.)
|October 26, 1999
Resumen
Las mutaciones del ADN mitocondrial (ADNmt) se acumulan con la edad, particularmente en regiones específicas de control de la replicación. Estas alteraciones del ADNmt relacionadas con la edad aparecen más tarde en la vida y pueden estar muy extendidas dentro de las células.
Área de la Ciencia:
- Biología Molecular Biología Molecular
- Genética La genética.
- Investigación sobre el envejecimiento Investigación sobre el envejecimiento
Sus antecedentes:
- El daño del ADN mitocondrial (ADNmt) es un contribuyente propuesto al envejecimiento.
- Estudios anteriores encontraron alteraciones limitadas del ADNmt, creando una discrepancia con las teorías del envejecimiento.
- El papel de las mutaciones del ADNmt en el proceso de envejecimiento requiere más investigación.
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