La actividad deteriorada del transportador de glucosa en la hipertrofia por sobrecarga de presión es un indicador temprano de la progresión a la falla
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1Department of Cardiac Surgery, The Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Circulation
|November 24, 1999
Resumen
El deterioro de la absorción de glucosa ocurre temprano en la hipertrofia cardíaca grave, que precede a la dilatación ventricular. Esta disminución en la utilización de la glucosa puede contribuir a la progresión de la insuficiencia cardíaca en los corazones hipertrofiados.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Regulación del metabolismo La regulación del metabolismo
- La hipertrofia cardíaca es una hipertrofia cardíaca.
Sus antecedentes:
- La hipertrofia cardíaca grave y la insuficiencia cardíaca son riesgos significativos en la cirugía cardíaca.
- La hipertrofia temprana implica un aumento de la relación entre la masa ventricular y el volumen de la cavidad (relación M / V) y la dependencia del metabolismo de la glucosa.
- La hipertrofia en etapa tardía muestra una disminución de la absorción de glucosa con dilatación ventricular y fallo.
Objetivo del estudio:
- Para investigar si el deterioro de la absorción de glucosa es una señal temprana de progresión de la hipertrofia.
- Para determinar si la absorción reducida de glucosa se correlaciona con el inicio de la dilatación ventricular.
Principales métodos:
- Los conejos se sometieron a una banda aórtica para inducir la hipertrofia.
- La ecocardiografía transtorácica midió la relación M/V del ventrículo izquierdo.
- (31) La espectroscopia de resonancia magnética nuclear P-P evaluó la tasa de absorción de glucosa en corazones perfundidos aislados a diferentes incrementos de la relación M/V.
Principales resultados:
- La absorción de glucosa se mantuvo normal en la hipertrofia compensada (aumento del 15% de la relación M/V).
- Se observó una absorción de glucosa significativamente reducida en la hipertrofia de descompensación temprana (aumento del 30% de la relación M / V).
- La expresión de la proteína transportadora de glucosa no cambió en todos los grupos.
Conclusiones:
- La absorción de glucosa se mantiene en la hipertrofia cardíaca compensada.
- La hipertrofia grave, que precede a la dilatación ventricular, muestra una disminución significativa de la absorción de glucosa.
- Este deterioro en la utilización de la glucosa puede contribuir a la progresión hacia la insuficiencia cardíaca.
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