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Updated: Jul 15, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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Published on: November 2, 2018

El estrés oxidativo induce la translocación nuclear de NF-kappaB sin degradación de IkappaBalpha

T G Canty1, E M Boyle, A Farr

  • 1Department of Surgery, University of Washington, Seattle 98104-2924, USA.

Circulation
|November 24, 1999
PubMed
Resumen

El estrés oxidativo activa el factor nuclear-kappaB (NF-kappaB) en las células cardíacas a través de una nueva vía. Este mecanismo evita la degradación habitual de IkappaBalpha, lo que sugiere un papel distinto para la fosforilación de tirosina en la señalización de NF-kappaB durante la lesión de isquemia-reperfusión.

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