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Prevalencia de parálisis supranuclear progresiva y atrofia de sistemas múltiples: un estudio transversal
A Schrag1, Y Ben-Shlomo, N P Quinn
1Department of Clinical Neurology, Institute of Neurology, London, UK.
Lancet (London, England)
|November 30, 1999
Resumen
La prevalencia en la población de parálisis supranuclear progresiva (PSP) y atrofia de sistemas múltiples (MSA) es más alta de lo que se pensaba anteriormente. Muchos individuos con estos trastornos parkinsonianos permanecen sin diagnosticar o mal diagnosticados en la comunidad.
Área de la Ciencia:
- Neurología Neurología.
- Epidemiología La epidemiología.
Sus antecedentes:
- La prevalencia en la población de la parálisis supranuclear progresiva (PSP) y la atrofia de sistemas múltiples (MSA) es en gran medida desconocida.
- Los estudios sugieren que estos trastornos parkinsonianos pueden ser subdiagnosticados en la población general.
Objetivo del estudio:
- Para investigar la prevalencia de la población de PSP y MSA.
- Para determinar si estas condiciones están subdiagnosticadas.
Principales métodos:
- Registros computarizados examinados de 15 consultas generales de Londres para diagnósticos relacionados con el parkinsonismo y el uso de medicamentos antiparkinsonianos.
- Evaluar a los pacientes elegibles a través de la revisión de registros, entrevistas, exámenes físicos y análisis de video para la confirmación del diagnóstico.
- Aplicó criterios diagnósticos publicados para los trastornos parkinsonianos, con un seguimiento de un año para los casos atípicos.
Principales resultados:
- La prevalencia ajustada por edad para la PSP fue de 6,4 por 100.000, y para la MSA fue de 4,4 por 100.000.
- Se identificaron un total de 11 casos probables o posibles para PSP y MSA combinados.
- Se identificaron cuatro casos atípicos adicionales que no cumplían con los criterios de PSP o MSA en el seguimiento.
Conclusiones:
- Es probable que la verdadera prevalencia de PSP y MSA se subestime en la población general.
- Un número significativo de pacientes con estos trastornos neurológicos permanecen sin diagnosticar o mal diagnosticados en la comunidad.
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