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Medium-throughput Screening Assays for Assessment of Effects on Ca2+-Signaling and Acrosome Reaction in Human Sperm
Published on: March 1, 2019
El estrógeno y la progesterona reducen la acumulación de lípidos en los macrófagos derivados de monocitos humanos: un
J A McCrohon1, S Nakhla, W Jessup
1Heart Research Institute and Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia.
Circulation
|December 11, 1999
Resumen
El estrógeno y la progesterona reducen la acumulación de lípidos en los macrófagos humanos, un paso clave en la aterosclerosis. Estos efectos son específicos de las mujeres, lo que sugiere un papel protector de estas hormonas.
Área de la Ciencia:
- Ciencias Cardiovasculares Ciencias Cardiovasculares
- Endocrinología Endocrinología.
- Biología celular Biología celular.
Sus antecedentes:
- El inicio y la prevalencia de la aterosclerosis difieren entre los sexos, lo que sugiere un papel protector para los esteroides sexuales femeninos.
- El estrógeno y la progesterona son esteroides sexuales femeninos clave implicados en la atheroprotección.
- La formación de células espumosas es un evento crítico temprano en la atherogénesis.
Objetivo del estudio:
- Para investigar los efectos del estrógeno y la progesterona en la formación de células de espuma humana.
- Para determinar si estos esteroides sexuales influyen en la acumulación de lípidos en los macrófagos.
Principales métodos:
- Los monocitos humanos se diferenciaron en macrófagos.
- Los macrófagos tratados con estrógeno o progesterona.
- Carga lipídica inducida por el LDL acetilado.
- Se analizó el contenido de éster de colesterol.
Principales resultados:
- El estrógeno y la progesterona redujeron significativamente el contenido de éster colesterol en los macrófagos derivados de la hembra.
- La progesterona demostró un efecto reductor de lípidos más potente que el estrógeno.
- Estos efectos estaban ausentes en los macrófagos de origen masculino y podrían ser bloqueados por un antagonista de la progesterona.
- Ambas hormonas alteraron la absorción y el procesamiento de LDL modificado por los macrófagos.
Conclusiones:
- El estrógeno y la progesterona reducen la carga lipídica en los macrófagos humanos de una manera específica para cada sexo.
- Estos hallazgos apoyan un papel ateroprotector para los niveles fisiológicos de estrógeno y progesterona en las mujeres.
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