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Riesgo de eventos coronarios agudos según las concentraciones séricas de enterolactona: un estudio prospectivo de
M Vanharanta1, S Voutilainen, T A Lakka
1Research Institute of Public Health, University of Kuopio, Finland.
Lancet (London, England)
|December 28, 1999
Resumen
Los altos niveles séricos de enterolactona en los hombres están relacionados con un riesgo reducido de eventos coronarios agudos. Esto sugiere que las dietas ricas en vegetales pueden proteger contra las enfermedades del corazón.
Área de la Ciencia:
- Salud Cardiovascular La salud cardiovascular.
- La epidemiología nutricional.
- Investigación del microbioma Investigación del microbioma.
Sus antecedentes:
- La enterolactona, un lignano producido por la microflora intestinal, se estudia por sus posibles efectos protectores contra el cáncer.
- El papel de la enterolactona en el riesgo de enfermedades cardiovasculares, específicamente eventos coronarios agudos, no está bien establecido.
Objetivo del estudio:
- Para investigar la asociación entre la concentración sérica de enterolactona y el riesgo de eventos coronarios agudos.
- Para explorar los posibles efectos cardioprotectores de la enterolactona en hombres de mediana edad.
Principales métodos:
- Se realizó un estudio prospectivo de casos y controles anidados en 2005 en hombres de mediana edad.
- La enterolactona sérica se midió utilizando el fluoroinmunoensayo de resolución temporal.
- 167 hombres con eventos coronarios agudos (casos) fueron emparejados con 167 controles sin enfermedad coronaria.
Principales resultados:
- La enterolactona sérica promedio fue menor en los casos (18,2 nmol/L) que en los controles (23,5 nmol/L).
- Los hombres en el cuarto más alto de enterolactona (> 30,1 nmol / L) tenían un riesgo 58.8% menor de eventos coronarios agudos.
- Esta reducción del riesgo persistió en un 65,3% después de ajustar por los principales factores de riesgo cardiovascular.
Conclusiones:
- Las concentraciones séricas más altas de enterolactona se asocian con un riesgo reducido de eventos coronarios agudos en hombres sanos.
- Los hallazgos apoyan la hipótesis de que las dietas ricas en alimentos de origen vegetal y ricos en fibra pueden reducir el riesgo de enfermedad coronaria.
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