Video Experimental Relacionado
Updated: May 22, 2026
09:26
How to Build a Vacuum Spring-transport Package for Spinning Rotor Gauges
Published on: April 7, 2016
Se requiere la expresión de ciclo de vrille para un reloj de Drosophila funcional
1Laboratory of Genetics, The Rockefeller University, New York, New York 10021, USA.
Cell
|December 28, 1999
Resumen
Los investigadores descubrieron un nuevo bucle de retroalimentación en Drosophila.
Área de la Ciencia:
- Cronobiología cronobiología.
- Biología Molecular Biología Molecular
- Genética La genética.
Sus antecedentes:
- Los ritmos circadianos son procesos biológicos endógenos que regulan los ciclos de sueño-vigilia y otras funciones fisiológicas.
- La mosca de la fruta Drosophila melanogaster sirve como organismo modelo para el estudio de los mecanismos del reloj circadiano.
- Los genes controlados por el reloj juegan un papel crucial en la regulación temporal de los procesos biológicos.
Objetivo del estudio:
- Identificar nuevos componentes y mecanismos reguladores del reloj circadiano de Drosophila.
- Para investigar el papel del gen vrille (vri) en el ritmo circadiano.
- Para aclarar la relación entre vri y otros genes de reloj conocidos.
Principales métodos:
- Realizó una prueba de detección de genes controlados por reloj en Drosophila.
- Utilizó análisis de ARN para medir los niveles de expresión génica.
- Realizó manipulaciones genéticas para evaluar la función de vrille.
- Ritmos de comportamiento observados en moscas de la fruta.
Principales resultados:
- Identificó vrille (vri), un factor de transcripción, como un gen controlado por el reloj.
- Se demostró que los niveles de ARN vri oscilan con un ritmo circadiano, regulado por dCLOCK y CYCLE.
- Demostró que el ciclo de vri es esencial para la expresión de genes de período y atemporales.
- Se encontró que la pérdida de ciclos de vri conduce a ritmos de comportamiento alterados, incluyendo largos períodos y arritmias.
- Se reveló que tanto dCLOCK como VRI regulan independientemente el factor de dispersión del pigmento (PDF).
Conclusiones:
- Se ha identificado un nuevo bucle regulador que involucra al vrille en el reloj circadiano de Drosophila.
- El ciclismo vrille es crucial para mantener el correcto funcionamiento del reloj circadiano de Drosophila.
- El gen vrille, junto con dCLOCK, influye en el factor de dispersión de pigmento de los neuropéptidos, lo que afecta los comportamientos manifiestos.
Videos de Conceptos Relacionados
01:26Cross-bridge Cycle
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
01:23Collar Bearings
Collar bearings are essential in various machines designed to support axial loads on rotating shafts. Depending on the specific application and requirements, they can be found with single or multiple collars.
01:21Rolling Resistance
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
01:17Rolling Resistance: Problem Solving
Rolling resistance, also known as rolling friction, is the force that resists the motion of a rolling object, such as a wheel, tire, or ball, when it moves over a surface. It is caused by the deformation of the object and the surface in contact with each other, as well as other factors like internal friction, hysteresis, and energy losses within the materials. Rolling resistance opposes the object's motion, requiring additional energy to overcome it and maintain movement. In practical...
01:09Rolling Without Slipping
People have observed the rolling motion without slipping ever since the invention of the wheel. For example, one can look at the interaction between a car's tires and the surface of the road. If the driver presses the accelerator to the floor so that the tires spin without the car moving forward, there must be kinetic friction between the wheels and the road's surface. If the driver slowly presses the accelerator, causing the car to move forward, the tires roll without slipping. It is essential...
01:09Rolle’s Theorem
Rolle’s Theorem states that if a real-valued function is continuous on a closed interval, differentiable on the open interval, and takes equal values at both endpoints, then there is at least one point within the open interval where the derivative of the function is zero.Rolle’s Theorem describes an important property of differentiable functions, this theorem applies to a real-valued function defined on a closed interval, provided three specific conditions are met. First, the function must be...