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Efecto del verapamil en la remodelación eléctrica auricular inducida por taquicardia a largo plazo
1Shin Kong Wu Ho-Su Memorial Hospital, National Yang-Ming University, Taiwan, ROC.
Circulation
|January 19, 2000
Resumen
El verapamil no impidió la remodelación eléctrica a largo plazo de la taquicardia en perros. Este medicamento también aumentó la duración de la fibrilación auricular (FA) tanto antes como después del ritmo.
Área de la Ciencia:
- Electrofisiología cardiovascular electrofisiología cardiovascular.
- Farmacología Farmacología.
Sus antecedentes:
- Los efectos a largo plazo del verapamil en la remodelación eléctrica auricular inducida por taquicardia siguen sin investigarse.
- La remodelación auricular es un factor clave en la fisiopatología de la fibrilación auricular (FA).
Objetivo del estudio:
- Investigar el impacto del verapamil en las propiedades electrofisiológicas auriculares durante y después del ritmo atrial rápido en un modelo canino.
- Para determinar si el verapamil puede prevenir o mitigar la remodelación eléctrica auricular inducida por taquicardia.
Principales métodos:
- Cuarenta y ocho perros fueron asignados al azar en verapamil y grupos de control.
- El período refractario efectivo auricular (AERP), la inducibilidad de la FA y la duración de la FA se evaluaron antes y después de 1 día, 1 semana o 6 semanas de ritmo atrial rápido.
- El verapamil se administró en dosis de 120 mg al día al grupo de verapamil.
Principales resultados:
- Verapamil atenuado acortamiento de AERP, dispersión, mala adaptación y inducibilidad de AF después de 1 día de ritmo.
- Estos efectos protectores no se observaron después de 1 semana o 6 semanas de ritmo.
- El verapamil prolongó significativamente la duración de la FA antes del ritmo y la aumentó después de 1 semana y 6 semanas de ritmo.
Conclusiones:
- El verapamil no previene los cambios electrofisiológicos auriculares inducidos por taquicardia a largo plazo.
- El verapamil exacerba la duración de la FA en el contexto de un ritmo auricular rápido sostenido.
- Estos hallazgos sugieren precaución al usar verapamil en pacientes con o en riesgo de fibrilación auricular.
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