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Regulación negativa de la activación de los linfocitos y la autoinmunidad por el adaptador molecular Cbl-bb

K Bachmaier1, C Krawczyk, I Kozieradzki

  • 1Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada.

Nature
|January 26, 2000
PubMed
Resumen

La proteína adaptadora Cbl-b es crucial para mantener la tolerancia inmune. Su ausencia en ratones conduce a la autoinmunidad debido a la activación incontrolada de los linfocitos y la producción de autoanticuerpos.

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