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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
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Video Experimental Relacionado

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Analysis of Trunk Neural Crest Cell Migration using a Modified Zigmond Chamber Assay
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La señalización nodal en el desarrollo de vertebrados.

A F Schier1, M M Shen

  • 1Department of Cell Biology, New York University School of Medicine, New York 10016, USA. schier@saturn.med.nyu.edu

Nature
|February 10, 2000
PubMed
Resumen
Este resumen es generado por máquina.

La comunicación celular a través de la vía de señalización nodal es crucial para establecer el plan corporal de los vertebrados durante la embriogénesis temprana. Esta vía regula los eventos clave del desarrollo, incluida la formación de ejes y el patrón de tejido.

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Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • La señalización celular de las células.
  • Biología molecular La biología molecular.

Sus antecedentes:

  • La comunicación celular es fundamental para la embriogénesis de los vertebrados y la organización del plan corporal.
  • La vía de señalización nodal, miembro de la superfamilia del factor de crecimiento transformador beta, juega un papel central en el desarrollo embrionario.

Objetivo del estudio:

  • Para aclarar el papel de la vía de señalización nodal en la embriogénesis de los vertebrados.
  • Comprender cómo la señalización nodal regula la formación del mesodermo y el endodermo, la especificación del eje y el patrón neural.

Principales métodos:

  • Investigó la vía de señalización Nodal y sus reguladores.
  • Centrado en la regulación extracelular por los cofactores EGF-CFC y los antagonistas Lefty/Cerberus.

Principales resultados:

  • La señalización nodal es esencial para configurar el embrión de los vertebrados.
  • Los reguladores extracelulares controlan con precisión la actividad nodal.
  • La actividad de la vía nodal influye en la formación del mesodermo / endodermo, el eje anterior-posterior, el patrón neural y la especificación del eje izquierda-derecha.

Conclusiones:

  • La vía de señalización nodal es un regulador clave del desarrollo temprano de los vertebrados.
  • La modulación extracelular de la actividad nodal por familias de proteínas específicas asegura un patrón embrionario preciso.