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Updated: Jun 13, 2026

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 6, 2013

Reversión de los cambios conformacionales de las proteínas priónicas por los péptidos disuasores de hojas beta

C Soto1, R J Kascsak, G P Saborío

  • 1New York University Medical Center, NY, USA. Caludio.Soto@serono.com

Lancet (London, England)
|February 16, 2000
PubMed
Resumen

Los péptidos que rompen la hoja beta pueden revertir el plegamiento anormal de la proteína priónica (PrP) asociado con las encefalopatías espongiformes transmisibles. Este tratamiento con péptidos redujo la infectividad de priones hasta en un 95% en ratones, ofreciendo una potencial estrategia terapéutica.

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