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Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Updated: Jul 8, 2026

Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue
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Isolation of Perivascular Multipotent Precursor Cell Populations from Human Cardiac Tissue

Published on: October 8, 2016

¿Por qué las células madre?

D van der Kooy1, S Weiss

  • 1Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada. derek.van.der.kooy@utoronto.ca

Science (New York, N.Y.)
|February 26, 2000
PubMed
Resumen

La mayoría de las células madre surgen tarde en el desarrollo para renovar los tejidos y asegurar la supervivencia a largo plazo. Sorprendentemente, las células madre adultas pueden reponer varios tejidos, desafiando la comprensión previa de su función.

Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • Biología de las células madre Biología de las células madre
  • Biología evolutiva Biología evolutiva.

Sus antecedentes:

  • Las células madre son cruciales para el desarrollo y mantenimiento de los tejidos.
  • Su origen y funciones precisas, particularmente en organismos adultos, son áreas de investigación en curso.
  • Comprender la función de las células madre es clave para la medicina regenerativa.

Objetivo del estudio:

  • Explorar los aspectos funcionales, evolutivos y de desarrollo de las células madre.
  • Para investigar el momento de la aparición de células madre durante el desarrollo del organismo.
  • Examinar el potencial de las células madre adultas en la reposición de tejidos.

Principales métodos:

  • Revisión de la literatura existente sobre la biología de las células madre.

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  • Análisis de los datos de desarrollo y evolución relacionados con los orígenes de las células madre.
  • Síntesis de hallazgos recientes sobre la plasticidad de las células madre adultas.

    • Principales resultados:

    • Las células madre pueden surgir predominantemente más tarde en el desarrollo en lugar de temprano.
    • La función principal de la mayoría de las células madre parece ser la renovación del tejido para la supervivencia a largo plazo.
    • Las células madre adultas específicas del tejido demuestran potencial para contribuir a múltiples tejidos adultos.

    Conclusiones:

    • La visión convencional del tiempo y la función de las células madre requiere una reevaluación.
    • La plasticidad de las células madre adultas ofrece nuevas vías para las intervenciones terapéuticas.
    • Se justifica una mayor investigación sobre los orígenes de las células madre y el potencial multi-tejido.