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La apoptosis neuronal inducida por virus bloqueada por la transcripción asociada a la latencia del virus del herpes
G C Perng1, C Jones, J Ciacci-Zanella
1Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns & Allen Research Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Science (New York, N.Y.)
|February 26, 2000
Resumen
La latencia del virus del herpes simple (HSV) implica un gen llamado transcripción asociada a la latencia (LAT). Este gen LAT es crucial para la reactivación del HSV y promueve la supervivencia neuronal al prevenir la apoptosis.
Área de la Ciencia:
- Virología Virología.
- La neurociencia es la neurociencia.
- Biología Molecular Biología Molecular
Sus antecedentes:
- Las infecciones latentes con reactivación periódica son comunes después de las infecciones virales agudas.
- El gen de transcripción asociada a la latencia (LAT, por sus siglas en inglés) es esencial para la reactivación del virus del herpes simple de tipo salvaje (HSV, por sus siglas en inglés).
- Los mecanismos precisos por los cuales la LAT influye en la latencia y la reactivación no se comprenden completamente.
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