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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
Rescate independiente de las células T de los linfocitos B de la tolerancia inmune periférica
V Kouskoff1, G Lacaud, D Nemazee
1Department of Pediatrics, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
Science (New York, N.Y.)
|March 31, 2000
Resumen
Los antígenos extraños que se imitan a sí mismos pueden romper la tolerancia de las células B, lo que lleva a células autorreactivas y respuestas autoinmunes. Este estudio revela un mecanismo clave para que las células B escapen de la auto-tolerancia.
Área de la Ciencia:
- Inmunología Inmunología.
- Investigación de la autoinmunidad.
- Inmunología molecular inmunología molecular.
Sus antecedentes:
- La autoinmunidad ocurre cuando el sistema inmune pierde la tolerancia a los autoantígenos.
- Los mecanismos de la ruptura de la auto-tolerancia no se comprenden completamente.
- Una hipótesis principal involucra la imitación molecular entre antígenos extraños y auto-antigenos.
Objetivo del estudio:
- Investigar cómo los antígenos extraños que imitan a los autoantígenos pueden interrumpir la auto-tolerancia de los linfocitos B.
- Para aclarar el papel de la ayuda de células T en este proceso.
- Identificar los mecanismos por los cuales las células B escapan a la tolerancia periférica.
Principales métodos:
- Utilizó un modelo de ratón de inmunoglobulina transgénica.
- Ratones desafiados con un antígeno extraño diseñado para imitar los autoantígenos.
- Se evaluó la tolerancia de las células B, la ayuda de las células T y la producción de inmunoglobulinas.
- Se analizó la acumulación de células autorreactivas en los ganglios linfáticos y el anticuerpo que se une a los autoantígenos.
Principales resultados:
- Desafío con autoimitación de antígenos extraños rescató a las células B de la tolerancia periférica.
- Este rescate se produjo independientemente de la ayuda de las células T.
- Las células B auto-reactivas se acumulan en los ganglios linfáticos.
- Las inmunoglobulinas secretadas por estas células B se unen a un autoantígeno expresado en el hígado.
Conclusiones:
- Los antígenos extraños que se autoimitan pueden inducir a las células B a escapar de la tolerancia periférica.
- Este mecanismo de escape opera independientemente de la activación dependiente de las células T.
- Los hallazgos revelan una vía significativa para la ruptura de la auto-tolerancia de los linfocitos B en la autoinmunidad.
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