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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
Published on: November 1, 2018
Manifestaciones neurológicas de la infección por dengue
T Solomon1, N M Dung, D W Vaughn
1Wellcome Trust Clinical Research Unit, Cho Quan Hospital, Ho Chi Minh City, Vietnam. tom.solomon@virgin.net
Lancet (London, England)
|April 1, 2000
Resumen
La infección por el virus del dengue puede causar enfermedades del sistema nervioso central (SNC), incluida la encefalitis, en áreas endémicas. La detección temprana del dengue es crucial en pacientes con síntomas neurológicos, incluso sin los signos típicos del dengue.
Área de la Ciencia:
- Arbovirología Arbovirología
- Neurología Neurología.
- Enfermedades infecciosas Enfermedades infecciosas.
Sus antecedentes:
- El dengue, una importante infección arboviral, es conocida por formas graves como la enfermedad hemorrágica y el síndrome de fuga vascular.
- El papel del virus del dengue en la causa de la enfermedad neurológica sigue siendo incierto.
Objetivo del estudio:
- Investigar la asociación entre la infección por el virus del dengue y las infecciones del sistema nervioso central (SNC) en el sur de Vietnam.
- Determinar la frecuencia y las manifestaciones clínicas de la enfermedad neurológica relacionada con el dengue.
Principales métodos:
- Investigación prospectiva de pacientes con sospecha de infecciones del SNC utilizando cultivos virales, PCR y detección de anticuerpos en suero y líquido cefalorraquídeo (LCR).
- Comparación con controles basados en el hospital.
- Análisis filogenético de cepas aisladas del virus del dengue.
Principales resultados:
- La infección por el virus del dengue se identificó en el 4,2% de los pacientes con infección del SNC, significativamente más alta que en los controles (1,4%).
- Las manifestaciones neurológicas incluyeron reducción de la conciencia y convulsiones; nueve pacientes presentaron encefalitis.
- Seis pacientes experimentaron secuelas neurológicas en el alta, sin fatalidades.
Conclusiones:
- El virus del dengue debe considerarse como una causa de encefalitis y encefalopatía en las regiones endémicas.
- Se recomienda la investigación para el dengue en pacientes con síntomas neurológicos, independientemente de la presencia de otras características relacionadas con el dengue.
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