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La duración de la señalización de los receptores de antígenos determina el destino del linaje de células T CD4 +

K Yasutomo1, C Doyle, L Miele

  • 1Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Nature
|April 13, 2000
PubMed
Resumen

La duración de la señalización del receptor de células T, influenciada por los co-receptores, determina si los timocitos se convierten en células T ayudantes CD4+ o en células T citotóxicas CD8+. La muesca-1 es crucial para la maduración de las células T CD8 +, no la elección inicial del linaje.

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