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El factor básico de crecimiento de los fibroblastos aumenta la expresión del factor tisular en los monocitos

D Corseaux¹, T Meurice, I Six

¹Laboratoire d'Hématologie, Centre Hospitalier Régional Universitaire and Faculté de Médecine, Lille, France.

|April 26, 2000

Resumen

El factor básico de crecimiento de fibroblastos (bFGF) aumenta la expresión del factor de tejido (TF) en monocitos y células vasculares en conejos. Este efecto es notable en conejos normales y menos pronunciado en los con hipercolesterolemia, lo que requiere una mayor investigación sobre el riesgo de trombosis.

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Área de la Ciencia:

Biología Vascular Biología Vascular
La hemostasis también es conocida como hemostasis.
Endocrinología Endocrinología.

Sus antecedentes:

Se sabe que el factor básico de crecimiento de fibroblastos (bFGF) promueve la reparación vascular y la angiogénesis.
bFGF puede inducir el factor de tejido (TF) in vitro, un iniciador clave de la trombogénesis.
El papel de la TF inducida por bFGF en la angiogénesis merece una investigación.

Objetivo del estudio:

Investigar si la administración sistémica de bFGF induce la expresión de TF en monocitos y células vasculares.
Para comparar la expresión de TF en conejos normales e hipercolesterolemicos después de la administración de bFGF.

Principales métodos:

La expresión de TF se estudió en conejos alimentados con colesterol normal y alimentados con colesterol.
Los animales recibieron bFGF intravenoso o inyecciones de solución salina.
La expresión de TF en monocitos y secciones aórticas se evaluó mediante inmunohistoquímica.

Principales resultados:

La administración de bFGF aumentó significativamente la expresión de monocitos TF tanto en conejos normales como en conejos con hipercolesterolemia.
La expresión de TF fue más baja en conejos con hipercolesterolemia en comparación con conejos normales.
bFGF indujo una fuerte expresión de TF en la pared vascular de conejos normales y una expresión débil en conejos con hipercolesterolemia.

Conclusiones:

La administración sistémica de bFGF aumenta notablemente la expresión de TF en los monocitos circulantes y la pared vascular.
El efecto de bFGF en la expresión de TF es más pronunciado en conejos normales que en conejos con hipercolesterolemia.
La importancia clínica de la expresión de TF inducida por bFGF con respecto a la trombosis in vivo requiere más estudios.