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La asociación del tromboembolismo venoso y la clozapina

S Hägg, O Spigset, T G Söderström

Lancet (London, England)

|May 3, 2000

Resumen

El uso de clozapina puede aumentar el riesgo de complicaciones tromboembólicas venosas, como coágulos de sangre. Este estudio revisó 12 casos, de los cuales cinco resultaron en muertes, lo que pone de relieve un efecto adverso potencial grave.

Área de la Ciencia:

Farmacovigilancia y farmacovigilancia también.
Toxicología Clínica Toxicología Clínica.
Hematología Hematología.

Sus antecedentes:

La clozapina es un medicamento antipsicótico atípico utilizado para la esquizofrenia resistente al tratamiento.
El tromboembolismo venoso (TEV) abarca la trombosis venosa profunda y la embolia pulmonar.
Las reacciones adversas a los medicamentos requieren un monitoreo y notificación continuos.

Objetivo del estudio:

Para investigar la asociación entre el tratamiento con clozapina y las complicaciones tromboembólicas venosas.
Para resumir los informes de casos de TEV en pacientes que reciben clozapina.

Principales métodos:

Revisión de los datos de casos presentados al Comité Consultivo Sueco de Reacciones Adversas.
Análisis de 12 casos reportados de tromboembolismo en pacientes tratados con clozapina.

Principales resultados:

El uso de clozapina se asoció con complicaciones tromboembólicas venosas en los casos revisados.
Cinco de los 12 casos reportados de TEV durante el tratamiento con clozapina fueron fatales.

Conclusiones:

Los hallazgos sugieren un posible vínculo entre la clozapina y un mayor riesgo de TEV.
Los proveedores de atención médica deben estar atentos a los signos de TEV en pacientes tratados con clozapina.
Se necesita más investigación para dilucidar el mecanismo y confirmar esta asociación.

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