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Moléculas de adhesión circulantes en humanos: el papel de la hiperglucemia y la hiperinsulinemia
R Marfella1, K Esposito, R Giunta
1Department of Geriatrics, Second University of Naples, Naples, Italy.
Circulation
|May 16, 2000
Resumen
La hiperglucemia aguda eleva la molécula de adhesión intercelular soluble-1 (sICAM-1) en personas sanas. En la diabetes tipo 2, la insulina o la L-arginina normalizan los niveles elevados de sICAM-1.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Biología Vascular Biología Vascular
- Trastornos metabólicos Los trastornos metabólicos son trastornos metabólicos que se producen en el cuerpo.
Sus antecedentes:
- Los niveles circulantes de la molécula de adhesión intercelular soluble-1 (sICAM-1) y la molécula de adhesión vascular-1 (sVCAM-1) están implicados en la inflamación vascular.
- Los roles de la glucosa y la insulina en la regulación de estas moléculas de adhesión no se comprenden completamente, particularmente en la diabetes tipo 2.
Objetivo del estudio:
- Investigar el impacto de la glucosa y la insulina en los niveles de sICAM-1 y sVCAM-1.
- Para comparar estos efectos en sujetos normales y pacientes con diabetes tipo 2.
Principales métodos:
- Se realizaron estudios de pinzas hiperglucémicas en sujetos normales y pacientes diabéticos tipo 2.
- La octreotida se usó para inhibir la liberación de insulina durante las abrazaderas.
- La euglucemia se logró utilizando un páncreas artificial o la suplementación con L-arginina en pacientes diabéticos.
Principales resultados:
- La hiperglucemia aguda aumentó significativamente los niveles de sICAM-1 en sujetos normales.
- Los pacientes diabéticos exhibieron niveles basales más altos de sICAM-1 en comparación con los controles.
- La inhibición de la insulina exacerbó la elevación de sICAM-1, mientras que la insulina o la L-arginina normalizaron sICAM-1 en los diabéticos.
Conclusiones:
- La hiperglucemia aguda es un estímulo para el aumento de la circulación de sICAM-1.
- La insulina y la L-arginina juegan un papel en la normalización de los niveles elevados de sICAM-1 en la diabetes tipo 2.
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