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Plasticidad neuronal: aumento de la ganancia en el dolor
1Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH-East, Charlestown, MA 02129, USA. woolf.clifford@mgh.harvard.edu
Science (New York, N.Y.)
|June 10, 2000
Resumen
El dolor involucra categorías distintas como los tipos fisiológicos, inflamatorios y neuropáticos. La plasticidad neural, la capacidad de las neuronas para cambiar, impulsa la patogénesis del dolor al aumentar la ganancia neural y causar hipersensibilidad al dolor.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Investigación del dolor Investigación del dolor.
- Biología celular Biología celular.
Sus antecedentes:
- El dolor es una sensación compleja con componentes fisiológicos, inflamatorios y neuropáticos.
- La plasticidad neuronal, la capacidad de las neuronas para alterar la función, la química o la estructura, está implicada en los mecanismos del dolor.
Objetivo del estudio:
- Establecer un marco conceptual para el papel de la plasticidad neural en la patogénesis del dolor.
- Para identificar formas específicas de plasticidad en las neuronas sensoriales que contribuyen al dolor.
Principales métodos:
- Desarrollo del marco conceptual. desarrollo del marco conceptual.
- Análisis de los mecanismos de plasticidad neural en las neuronas primarias sensoriales y del cuerno dorsal.
Principales resultados:
- Se identificaron tres formas distintas de plasticidad neural: activación, modulación y modificación.
- Estas formas de plasticidad aumentan la ganancia neuronal, lo que lleva a la hipersensibilidad al dolor.
Conclusiones:
- La plasticidad neural en las neuronas primarias sensoriales y del cuerno dorsal es fundamental para la patogénesis del dolor.
- Diferentes mecanismos de plasticidad contribuyen al desarrollo y mantenimiento de los estados de dolor.
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