Videos de Conceptos Relacionados
00:58Genomic DNA in Eukaryotes
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
02:02Genomics
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
03:21Genome Size and the Evolution of New Genes
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
02:54Evolutionary Relationships through Genome Comparisons
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
03:36Genome Annotation and Assembly
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
03:21Genome Size and the Evolution of New Genes
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
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Video Experimental Relacionado
Updated: May 11, 2026
22:27
Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
Published on: May 7, 2010
Explorando el espacio del genoma.
1Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
Nature
|June 24, 2000
Resumen
La biología está generando grandes cantidades de datos del genoma, lo que impulsa el desarrollo de nuevas tecnologías. Estas innovaciones tienen como objetivo explorar funciones celulares complejas y desbloquear nuevos conocimientos biológicos.
Área de la Ciencia:
- La genómica es la genómica.
- Biología Molecular Biología Molecular
- La bioinformática es la bioinformática.
Sus antecedentes:
- La rápida finalización de numerosas secuencias del genoma completo, incluido el genoma humano, ha creado un aumento sin precedentes en los datos biológicos.
- Esta explosión de datos presenta desafíos y oportunidades para la investigación biológica.
Objetivo del estudio:
- Para resaltar la necesidad crítica de nuevos avances tecnológicos en respuesta al creciente volumen de datos basados en el genoma.
- Hacer hincapié en el cambio hacia preguntas de investigación impulsadas por el genoma en la biología moderna.
Principales métodos:
- Desarrollo de tecnologías innovadoras para el análisis de datos del genoma.
- Aplicación de nuevos métodos para investigar la complejidad celular.
Principales resultados:
- Aparición de nuevas vías de investigación centradas en las investigaciones basadas en el genoma.
- Mayor capacidad para abordar cuestiones complejas relacionadas con los mecanismos celulares.
- Aceleración del descubrimiento biológico a través de la utilización avanzada de datos.
Conclusiones:
- La era de la secuenciación completa del genoma requiere la rápida evolución de las tecnologías de investigación.
- Las nuevas tecnologías son esenciales para que los científicos aprovechen plenamente los datos del genoma y profundicen nuestra comprensión de la vida.