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Videos de Conceptos Relacionados

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Conservation of Protein Domains Over Different Proteins02:26

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Ribosome Profiling02:24

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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The Central Dogma01:20

The Central Dogma

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
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La función de las proteínas en la era post-genómica.

D Eisenberg1, E M Marcotte, I Xenarios

  • 1Molecular Biology Institute and UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, University of California at Los Angeles, 90095-1570, USA. david@mbi.ucla.edu

Nature
|June 24, 2000
PubMed
Resumen
Este resumen es generado por máquina.

La genómica funcional tiene como objetivo transformar vastos datos genómicos en conocimiento biológico. Este campo aborda cómo sintetizar la secuencia y los datos de expresión de ARN mensajero en información significativa.

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Área de la Ciencia:

  • La genómica es la genómica.
  • Biología Molecular Biología Molecular
  • La bioinformática es la bioinformática.

Sus antecedentes:

  • La investigación biológica está generando cantidades masivas de datos genómicos y de expresión de ARN mensajero (ARNm).
  • El desafío radica en convertir este diluvio de datos en conocimiento científico procesable.
  • Los métodos actuales de procesamiento de datos tienen dificultades para sintetizar eficazmente la información biológica diversa.

Objetivo del estudio:

  • Para explorar el campo emergente de la genómica funcional.
  • Para abordar la cuestión crítica de cómo obtener un conocimiento significativo de los extensos datos genómicos y de expresión.
  • Definir las posibles formas y aplicaciones del conocimiento generado por la genómica funcional.

Principales métodos:

  • Análisis de las tendencias actuales en la generación de datos genómicos.
  • Revisión de las técnicas de elaboración de perfiles de expresión de alto rendimiento (por ejemplo, microarrays).
  • Desarrollo de un marco conceptual para la síntesis del conocimiento en biología.

Principales resultados:

  • Identificó una brecha significativa entre la generación de datos y la adquisición de conocimientos en biología.
  • Destacó la necesidad de nuevos enfoques para integrar e interpretar conjuntos de datos biológicos complejos.
  • Estableció la genómica funcional como una disciplina clave para abordar este desafío.

Conclusiones:

  • La genómica funcional ofrece una vía para traducir datos biológicos a gran escala en el entendimiento biológico.
  • La síntesis efectiva de datos genómicos y de expresión es crucial para avanzar en el descubrimiento biológico.
  • El campo promete remodelar la forma en que se genera y utiliza el conocimiento biológico.