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Videos de Conceptos Relacionados

What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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RNA-seq03:21

RNA-seq

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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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What is Gene Expression?01:36

What is Gene Expression?

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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Video Experimental Relacionado

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Global Gene Expression Analysis Using a Zebrafish Oligonucleotide Microarray Platform
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Global Gene Expression Analysis Using a Zebrafish Oligonucleotide Microarray Platform

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Genómica, expresión génica y matrices de ADN.

D J Lockhart1, E A Winzeler

  • 1Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.

Nature
|June 24, 2000
PubMed
Resumen

La investigación genómica utiliza matrices de ADN para estudiar las células y los procesos. Estas matrices permiten la medición simultánea de la expresión génica de miles de genes, lo que hace avanzar la comprensión biológica.

Área de la Ciencia:

  • La genómica es la genómica.
  • Biología Molecular Biología Molecular
  • La bioinformática es la bioinformática.

Sus antecedentes:

  • La información de la secuencia genómica se está expandiendo rápidamente.
  • Se necesitan nuevos enfoques experimentales para analizar estos datos.
  • La comprensión de los procesos celulares requiere el análisis de datos a gran escala.

Objetivo del estudio:

  • Explorar la aplicación de la información de secuencia genómica en la biología experimental.
  • Para resaltar la utilidad de las matrices de ADN de alta densidad en la investigación biológica.
  • Para demostrar cómo la genómica puede revolucionar el estudio de las células y los procesos celulares.

Principales métodos:

  • Utilizando matrices de ADN de alta densidad para interrogar mezclas de ARN y ADN.

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  • Empleando el análisis paralelo y cuantitativo de muestras biológicas.
  • Aprovechar la información de la secuencia genómica para el diseño experimental y la interpretación de datos.

    • Principales resultados:

    • Las matrices de ADN permiten la medición simultánea de la expresión génica para decenas de miles de genes.
    • Las matrices de alta densidad permiten el análisis cuantitativo de mezclas biológicas complejas.
    • Los enfoques genómicos proporcionan una visión amplia y a gran escala de las funciones celulares.

    Conclusiones:

    • La genómica experimental, particularmente el uso de matrices de ADN, ofrece un enfoque poderoso para el estudio biológico.
    • La integración de datos de secuencia genómica con técnicas experimentales revoluciona la comprensión celular y de procesos.
    • La genómica permite investigaciones completas y a gran escala en los sistemas biológicos.