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Prueba de la hipótesis priónica: inducción del factor [PSI+] de la levadura por la proteína Sup35 convertida in vitro

H E Sparrer1, A Santoso, F C Szoka

  • 1Department of Cellular and Molecular Pharmacology and Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94143-0450, USA.

Science (New York, N.Y.)
|August 1, 2000
PubMed
Resumen

Los investigadores crearon un agente infeccioso a partir de una proteína de levadura modificada (Sup35p) que induce el estado priónico [PSI+]. Esto demuestra que las proteínas pueden actuar como agentes infecciosos, causando cambios conformacionales de autopropagación en las células.

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