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P50 Sensory Gating in Infants
Published on: December 26, 2013
Circuitos neuronales nociceptivos alterados después de la inflamación periférica neonatal
M A Ruda1, Q D Ling, A G Hohmann
1Cellular Neuroscience Section, Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH), Bethesda, MD 20892, USA. maruda@dir.nidcr.nih.gov
Science (New York, N.Y.)
|August 1, 2000
Resumen
El dolor neonatal de los procedimientos médicos puede alterar los circuitos de detección del dolor. La lesión temprana de los tejidos en los recién nacidos conduce a cambios duraderos en las vías del dolor de la médula espinal en la edad adulta.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología del desarrollo Biología del desarrollo.
- Investigación del dolor Investigación del dolor.
Sus antecedentes:
- Los circuitos nociceptivos se desarrollan durante los primeros años de vida cuando el dolor es mínimo.
- Los procedimientos médicos neonatales pueden causar dolor y lesiones tisulares.
- Las consecuencias a largo plazo del dolor neonatal en el desarrollo neurológico son en gran medida desconocidas.
Objetivo del estudio:
- Investigar el impacto de la lesión del tejido neonatal y el dolor en el desarrollo del circuito neuronal nociceptivo.
- Para entender los efectos a largo plazo de la exposición temprana al dolor.
Principales métodos:
- Utilizó un modelo animal de inflamación periférica persistente de la pata trasera en neonatos.
- Circuitos neuronales espinales examinados y cambios en el axón aferente primario en la edad adulta.
Principales resultados:
- Los animales adultos expuestos a la inflamación neonatal mostraron un aumento de la entrada neuronal espinal.
- Se observaron alteraciones segmentales en los axones aferentes primarios nociceptivos.
- Las respuestas a la estimulación sensorial se modificaron en la edad adulta.
Conclusiones:
- La inflamación periférica neonatal puede conducir a alteraciones persistentes y a largo plazo en los circuitos nociceptivos espinales.
- La exposición al dolor temprano en la vida puede tener impactos duraderos en el procesamiento sensorial y las vías del dolor.
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