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Efecto de la talidomida en los efectos gastrointestinales tóxicos del irinotecán
Lancet (London, England)
|August 19, 2000
Resumen
La talidomida combinada con quimioterapia con irinotecán es prometedora para el cáncer colorrectal metastásico. Esta combinación redujo significativamente los efectos secundarios gastrointestinales graves, permitiendo a más pacientes completar el tratamiento.
Área de la Ciencia:
- Oncología Oncología.
- Farmacología Farmacología.
Sus antecedentes:
- El irinotecán es un tratamiento clave de segunda línea para el cáncer colorrectal.
- La diarrea y las náuseas de aparición tardía con frecuencia limitan la dosis de irinotecan.
- La talidomida exhibe efectos antiangiogénicos e inmunomoduladores, con una potencial actividad antineoplásica.
Objetivo del estudio:
- Evaluar la seguridad y tolerabilidad de la terapia de combinación con talidomida e irinotecán.
- Para evaluar el impacto de la talidomida en las toxicidades gastrointestinales inducidas por el irinotecan.
Principales métodos:
- Estudio piloto que incluye terapia de combinación.
- Análisis intermedio de nueve pacientes con cáncer colorrectal metastásico.
Principales resultados:
- La talidomida redujo significativamente la diarrea asociada al irinotecan (p<0.0001).
- Las náuseas asociadas con el irinotecan también se redujeron significativamente (p<0.0001).
- Ocho de los nueve pacientes completaron con éxito su ciclo de quimioterapia.
Conclusiones:
- La terapia de combinación con talidomida e irinotecán parece mitigar las toxicidades clave que limitan la dosis.
- Esta combinación puede mejorar las tasas de finalización del tratamiento en pacientes con cáncer colorrectal metastásico.
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