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La isquemia posterior al ejercicio está asociada con un aumento del neuropéptido Y en pacientes con enfermedad
L Gullestad1, B Jorgensen, T Bjuro
1Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway. lagulles@online.no
Circulation
|August 30, 2000
Resumen
Los niveles de neuropéptido Y (NPY) se correlacionan con la isquemia miocárdica inducida por el ejercicio en pacientes con enfermedad arterial coronaria. Los niveles más altos de NPY están relacionados con una mayor depresión del segmento ST y tiempos de recuperación más largos, lo que sugiere NPY.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- La neuroendocrinología en neuroendocrinología.
Sus antecedentes:
- Las neurohormonas influyen en el tono vascular durante y después del ejercicio.
- El neuropéptido Y (NPY), liberado conjuntamente con la norepinefrina, es un potente vasoconstrictor.
Objetivo del estudio:
- Investigar la asociación entre el neuropéptido Y (NPY) y la isquemia miocárdica inducida por el ejercicio en pacientes con enfermedad arterial coronaria.
Principales métodos:
- Se realizaron pruebas de ejercicio limitado a los síntomas en 29 pacientes masculinos con angina de pecho.
- Los cambios en el segmento ST se analizaron utilizando métodos convencionales y pendientes / bucles de recuperación ajustados por HR.
- Los niveles plasmáticos de neurohormonas (NPY, NE, epinefrina, NT-proANP, endotelina grande) se midieron antes, durante y después del ejercicio.
Principales resultados:
- El ejercicio indujo una depresión significativa del segmento ST y aumentó los niveles plasmáticos de NPY, norepinefrina (NE) y epinefrina.
- NPY y NT-proANP alcanzaron su pico 4 minutos después del ejercicio, a diferencia de NE y epinefrina que alcanzaron su pico en el ejercicio máximo.
- El aumento máximo de NPY se correlacionó significativamente con la depresión del segmento ST, el déficit de ST y la duración de la depresión de ST después del ejercicio.
Conclusiones:
- Los niveles plasmáticos de NPY se correlacionan con la gravedad y la duración de la depresión del segmento ST después del ejercicio en pacientes con enfermedad arterial coronaria.
- NPY puede desempeñar un papel en la contribución a la isquemia miocárdica en esta población de pacientes.
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