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El estrés oxidante y la biosíntesis de tromboxano insensible a la aspirina en la angina de pecho inestable grave

F Cipollone¹, G Ciabattoni, P Patrignani

¹Department of Medicine and Aging, University of Chieti "G. D'Annunzio" School of Medicine, Chieti, Italy.

|August 30, 2000

Resumen

La angina inestable eleva la producción de F(2)-isoprostano, relacionado con la biosíntesis de tromboxano resistente a la aspirina. Esto sugiere que los antioxidantes pueden ayudar a controlar la angina inestable al reducir el estrés oxidante.

Área de la Ciencia:

Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
La bioquímica es la bioquímica.
El estrés oxidativo Investigación de la investigación

Sus antecedentes:

La angina inestable se caracteriza por un aumento de la peroxidación lipídica y una disminución de la capacidad antioxidante.
Investigaciones anteriores indicaron la ineficacia de la aspirina en la supresión de la biosíntesis de tromboxano durante ciertos episodios de activación plaquetaria en la angina inestable.
Este estudio investiga el papel de la 8-iso-prostaglandina F ((2alfa) (8-iso-PGF ((2alfa)), un marcador de la peroxidación lipídica, en la angina inestable y su posible contribución a la producción de tromboxano insensible a la aspirina.

Objetivo del estudio:

Para determinar si la formación in vivo de 8-iso-PGF ((2alfa) está elevada en la angina inestable.
Investigar la asociación entre el 8-iso-PGF2alfa mejorado y la biosíntesis de tromboxano insensible a la aspirina.
Explorar la relación entre los niveles de 8-iso-PGF, la producción de tromboxano y el estado antioxidante en pacientes con angina inestable.

Principales métodos:

Se recogieron muestras de orina de pacientes con angina inestable (n=32), angina estable (n=32), angina variante (n=4) y controles sanos (n=40).
Se midieron en la orina el 8-iso-PGF{2alfa) y el 11-dehidrotromboxano B{2} (TXB{2}) utilizando análisis inmunológicos.
Los niveles correlacionados de 8-iso-PGF{2alfa) con la excreción de 11-dehidro-TXB{2} y las concentraciones plasmáticas de vitamina E.

Principales resultados:

La excreción urinaria de 8-iso-PGF ((2alfa) fue significativamente mayor en pacientes con angina inestable en comparación con pacientes con angina estable y controles sanos.
Se observó una correlación lineal positiva significativa entre la excreción de 8-iso-PGF2alfa y 11-dehidro-TXB2 en pacientes con angina inestable.
Los niveles elevados de 8-iso-PGF ((2alfa) estaban inversamente correlacionados con los niveles plasmáticos de vitamina E, lo que indica una reducción de la defensa antioxidante.

Conclusiones:

El estudio establece un vínculo bioquímico entre el aumento del estrés oxidante y la biosíntesis de tromboxano insensible a la aspirina en la angina inestable.
Los hallazgos sugieren que un nivel elevado de 8-iso-PGF ((2alfa) juega un papel en la fisiopatología de la angina inestable.
Estos resultados proporcionan una justificación científica para investigar la eficacia de los antioxidantes en el manejo de la angina inestable.

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