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Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
Síndrome de Gilbert y hiperbilirrubinaemia en recién nacidos incompatibles con ABO
Lancet (London, England)
|September 1, 2000
Resumen
El síndrome de Gilbert, un polimorfismo promotor del gen UGT, aumenta significativamente el riesgo de hiperbilirrubinemia neonatal en los bebés directos de Coombs negativos a la ABO. Este factor genético es crucial para comprender la ictericia severa en estos recién nacidos.
Área de la Ciencia:
- Medicina Neonatal La medicina neonatal es una especialidad de la medicina neonatal.
- Genética Clínica Genética clínica.
- Farmacogenética La farmacogenética.
Sus antecedentes:
- Investigó el papel del polimorfismo promotor del gen UDP glucuronosiltransferasa (UGT) (síndrome de Gilbert) en la hiperbilirrubinemia neonatal.
- Centrado en los recién nacidos incompatibles con ABO negativos directos de Coombs, un escenario clínico específico.
- Comparación de frecuencias alélicas entre cohortes infantiles incompatibles con ABO y compatibles con ABO.
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