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Enfermedad coronaria en fumadores: la vitamina C restaura la función microcirculatoria coronaria La vitamina C
P A Kaufmann1, T Gnecchi-Ruscone, M di Terlizzi
1MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
Circulation
|September 12, 2000
Resumen
Fumar afecta el flujo sanguíneo coronario tanto en las arterias grandes como en la microcirculación debido al estrés oxidativo. El antioxidante vitamina C restauró la reserva de flujo coronario en los fumadores, destacando su potencial papel terapéutico.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- El estrés oxidativo Investigación de la investigación
- Farmacología Farmacología.
Sus antecedentes:
- Los fumadores sin enfermedad coronaria muestran deterioro de la función endotelial coronaria y la vasomoción.
- El aumento del estrés oxidativo es la causa sospechosa de estas deficiencias vasculares en los fumadores.
Objetivo del estudio:
- Investigar el impacto del tabaquismo en la microcirculación coronaria y la regulación del flujo sanguíneo miocárdico.
- Para determinar si la vitamina C puede restaurar la reserva de flujo coronario en fumadores.
Principales métodos:
- La tomografía por emisión de positrones se utilizó para medir la reserva de flujo coronario en 11 fumadores y 8 sujetos de control.
- Se tomaron medidas antes y después de la administración del antioxidante vitamina C.
Principales resultados:
- La reserva de flujo coronario basal fue un 21% más baja en los fumadores en comparación con los controles (P<0,05).
- La vitamina C normalizó la reserva de flujo coronario en los fumadores, pero no tuvo ningún efecto en los controles.
- Esto sugiere que los efectos prooxidantes del tabaquismo se extienden a la microcirculación coronaria.
Conclusiones:
- El estrés oxidativo inducido por el tabaquismo afecta la microcirculación coronaria y la regulación del flujo sanguíneo miocárdico.
- La administración de vitamina C restaura la capacidad de respuesta microcirculatoria coronaria y la reserva de flujo coronario alterado en fumadores.
- Estos hallazgos proporcionan evidencia de que el estrés oxidativo contribuye significativamente al daño vascular del tabaquismo.
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