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El mecanismo estructural de STI-571 es la inhibición de la tirosina quinasa de abelson

T Schindler1, W Bornmann, P Pellicena

  • 1Laboratories of Molecular Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Science (New York, N.Y.)
|September 16, 2000
PubMed
Resumen

Los inhibidores de la tirosina quinasa (Abl) de Abelson como el STI-571 tratan la leucemia mielógena crónica (LMC). Las estructuras cristalinas revelan que STI-571 se une a Abl mediante la estabilización de una conformación de quinasa inactiva, crucial para el diseño de fármacos dirigidos.

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