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Videos de Conceptos Relacionados

Organization of Genes02:07

Organization of Genes

Overview
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Organization of Genes02:07

Organization of Genes

Overview
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...

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Video Experimental Relacionado

Updated: Jul 5, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

La genómica ocurre cuando sucede.

V J DiRita1

  • 1Department of Microbiology and Immunology and Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Science (New York, N.Y.)
|September 19, 2000
PubMed
Resumen

El cólera, una enfermedad diarreica grave causada por el Vibrio cholerae, ha plagado a la humanidad durante siglos. La secuenciación genómica ahora está descubriendo nuevos conocimientos sobre cómo este peligroso microbio causa enfermedades.

Área de la Ciencia:

  • Microbiología Microbiología.
  • La genómica es la genómica.
  • Enfermedades infecciosas Enfermedades infecciosas.

Sus antecedentes:

  • El cólera sigue siendo una amenaza significativa para la salud mundial, ya que históricamente ha causado epidemias generalizadas.
  • El agente causante, Vibrio cholerae, es una bacteria acuática que puede infectar a los humanos.
  • Comprender su patogénesis es crucial para desarrollar estrategias efectivas de control.

Objetivo del estudio:

  • Explorar los avances recientes en la comprensión de la patogénesis del Vibrio cholerae.
  • Para resaltar el papel de la secuenciación genómica en la revelación de nuevos conocimientos.

Principales métodos:

  • Secuenciación genómica del Vibrio cholerae.
  • Análisis de las interacciones patógeno-anfitrión.

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Videos de Experimentos Relacionados

Last Updated: Jul 5, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
06:30

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM

Published on: March 2, 2017

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
08:57

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

Principales resultados:

  • Los datos genómicos están proporcionando nuevas perspectivas sobre los mecanismos causantes de enfermedades del Vibrio cholerae.
  • Se están descubriendo nuevas facetas de la patogénesis microbiana.

Conclusiones:

  • Las ideas genómicas están revolucionando nuestra comprensión del cólera.
  • La investigación continua sobre la genómica del Vibrio cholerae mejorará los esfuerzos de control de enfermedades.