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Los terminales nerviosos GABAérgicos inhibidores disminuyen en los sitios de epilepsia focal
Science (New York, N.Y.)
|July 13, 1979
Resumen
La epilepsia en monos muestra una disminución significativa en las terminales nerviosas del ácido gamma-aminobutírico (GABA) en las áreas de las convulsiones. Esta pérdida de la inhibición GABAérgica puede causar actividad epiléptica en las neuronas corticales.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La neuroquímica es la neuroquímica.
Sus antecedentes:
- El ácido gamma-aminobutírico (GABA) es el principal neurotransmisor inhibidor en el sistema nervioso central de los mamíferos.
- La descarboxilasa del ácido glutámico (GAD) es la enzima responsable de la síntesis del GABA.
Objetivo del estudio:
- Para investigar la distribución de los terminales nerviosos GABAérgicos en la corteza sensorimotora de monos normales y epilépticos.
- Para determinar si hay cambios en los terminales GABAérgicos en los focos de convulsión.
Principales métodos:
- Se utilizó inmunocitoquímica para localizar las terminales nerviosas positivas para GAD.
- Se realizó un análisis ultrastructural en las terminales nerviosas.
- Los monos fueron inducidos a un estado epiléptico mediante la aplicación de gel de alumina en la corteza.
Principales resultados:
- Se encontraron terminales nerviosos GABAérgicos en todas las capas de la corteza sensorimotora normal del mono.
- Estas terminales parecían originarse de las neuronas estelares aspinosas y escasamente espinosas.
- Se observó una disminución numérica significativa en los terminales nerviosos positivos para GAD en los focos de convulsiones en monos epilépticos.
Conclusiones:
- El estudio indica una pérdida funcional de las sinapsis inhibidoras GABAérgicas en los focos de convulsión en monos epilépticos.
- Esta pérdida de inhibición podría contribuir a la actividad epiléptica observada en las neuronas piramidal cortical.
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