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El estrés y los factores de afrontamiento influyen en el crecimiento del tumor
Science (New York, N.Y.)
|August 3, 1979
Resumen
El estrés afecta el crecimiento del tumor. Una sola descarga inevitable aceleró el crecimiento del mastocitoma P815 y acortó la supervivencia en ratones, mientras que las descargas evasivas no tuvieron ningún efecto. La exposición al estrés a largo plazo mitigó estos impactos negativos.
Área de la Ciencia:
- Inmunología Inmunología.
- Oncología Oncología Oncología.
- Fisiología del estrés Fisiología del estrés
Sus antecedentes:
- La relación entre el estrés y la progresión del cáncer es compleja.
- Comprender cómo los diferentes tipos de estrés influyen en el crecimiento tumoral es crucial para desarrollar terapias de apoyo.
Objetivo del estudio:
- Investigar el impacto de diferentes regímenes de estrés en el crecimiento del mastocitoma P815 en ratones machos DBA/2J.
- Determinar si la naturaleza y la duración de la exposición al estrés modifican sus efectos en el desarrollo del tumor y la supervivencia del huésped.
Principales métodos:
- Los ratones fueron sometidos a sesiones individuales de estrés de choque inevitable o evasivo.
- El crecimiento del tumor, el tamaño y la supervivencia de los animales fueron monitoreados.
- Un grupo separado recibió tratamiento de choque a largo plazo para evaluar los efectos de la habituación.
Principales resultados:
- Una sola sesión de choque inevitable aceleró significativamente la aparición del tumor y aumentó el tamaño del tumor.
- El choque inevitable también condujo a una marcada disminución en el tiempo de supervivencia de los ratones portadores de tumores.
- El choque evasivo no produjo ningún efecto significativo en el crecimiento tumoral o la supervivencia.
- La exposición previa a largo plazo al estrés de choque mitigó los efectos adversos del choque agudo inevitable.
Conclusiones:
- El estrés agudo e ineludible puede promover el crecimiento tumoral e impactar negativamente en la supervivencia.
- El tipo y la duración de la exposición al estrés son factores críticos que modulan su influencia en el cáncer.
- Estos hallazgos sugieren mecanismos potenciales por los cuales el estrés puede influir en la progresión del cáncer y resaltan la importancia del manejo del estrés en la atención del cáncer.
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