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Frecuencia de las anomalías coroidales en la neurofibromatosis tipo 1
T Yasunari1, K Shiraki, H Hattori
1Department of Ophthalmology, Osaka City University Medical School, Osaka, Japan. taka@med.osaka-cu.ac.jp
Lancet (London, England)
|October 21, 2000
Resumen
La neurofibromatosis 1 comúnmente afecta a la coroide, revelando anomalías a través de imágenes infrarrojas y angiografía verde indocianina. Estos hallazgos, indetectables por métodos convencionales, resaltan el coroide.
Área de la Ciencia:
- Oftalmología Oftalmología.
- Imágenes médicas de imágenes médicas.
- Genética La genética.
Sus antecedentes:
- La neurofibromatosis 1 (NF1) es un trastorno genético con varias manifestaciones oculares.
- La participación coroidal en la NF1 ha sido históricamente difícil de evaluar.
- Los avances en imágenes, incluida la oftalmoscopia láser de barrido (SLO) y la angiografía verde de indocianina (ICGA), permiten un examen coroidal detallado.
Objetivo del estudio:
- Para investigar las anomalías coroidales en pacientes con neurofibromatosis 1.
- Para comparar la frecuencia de las anomalías coroidales con otros hallazgos oculares en NF1.
- Evaluar la utilidad del SLO infrarrojo e ICGA en la detección de estos cambios.
Principales métodos:
- Se examinaron 33 ojos de 17 pacientes con NF1 utilizando oftalmoscopia convencional y SLO confocal infrarrojo.
- Los hallazgos se compararon con 76 ojos de 39 controles de edad igualada utilizando SLO confocal.
- Realizó angiografía con fluoresceína e ICGA en 11 pacientes adultos con NF1 y controles.
Principales resultados:
- Todos los 33 ojos NF1 exhibieron regiones irregulares brillantes en el polo posterior a través de SLO. infrarrojo.
- Estas regiones correspondían a áreas hipofluorescentes en ICGA, lo que indicaba anormalidades coroidales.
- La oftalmoscopia convencional y la angiografía con fluoresceína no revelaron anormalidades; los controles no mostraron ninguna.
Conclusiones:
- El SLO infrarrojo y el ICGA detectan anormalidades coroidales no reconocidas previamente en NF1.1.
- La alta prevalencia (100%) sugiere que la coroide es un objetivo primario en la neurofibromatosis 1.
- Estas técnicas de imagen son cruciales para diagnosticar y comprender la participación ocular en la NF1.
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