Video Experimental Relacionado
Updated: Jun 21, 2026
12:55
Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
Published on: February 16, 2015
La bioquímica de la apoptosis
1Cold Spring Harbor Laboratory, New York 11724, USA. hengartn@cshl.org
Nature
|October 26, 2000
Resumen
La apoptosis, o muerte celular programada, es un proceso complejo regulado por numerosos genes. Esta revisión detalla los componentes centrales, las interacciones y las vías de activación de este mecanismo esencial de autodestrucción celular.
Área de la Ciencia:
- Biología celular Biología celular.
- Biología Molecular Biología Molecular
- Genética La genética.
Sus antecedentes:
- La apoptosis es un proceso celular estrictamente regulado esencial para el desarrollo y la homeostasis tisular.
- La decisión de someterse a la apoptosis está influenciada por una compleja interacción de factores genéticos.
- La ejecución adecuada de la apoptosis requiere la activación coordinada de múltiples subprogramas celulares.
Objetivo del estudio:
- Revisar los componentes fundamentales de la maquinaria celular involucrada en la apoptosis.
- Describir las interacciones que regulan la apoptosis de una manera coordinada.
- Para discutir las vías primarias que inician la muerte celular programada.
Principales métodos:
- Revisión de la literatura de la investigación existente sobre la apoptosis.
- Análisis de los mecanismos genéticos y moleculares que rigen la muerte celular.
- Síntesis de información sobre las vías apoptóticas y su regulación.
Principales resultados:
- Identificación de los actores moleculares clave en el proceso apoptótico.
- Elucidación de las interacciones coordinadas entre diferentes subprogramas apoptóticos.
- Visión general de las principales vías de señalización que conducen a la apoptosis.
Conclusiones:
- La apoptosis es un proceso complejo y regulado genéticamente que involucra intrincadas interacciones moleculares.
- Comprender estas vías es crucial para comprender el destino celular y desarrollar estrategias terapéuticas.
- La revisión proporciona una visión general completa de los mecanismos y la regulación de la muerte celular programada.
Videos de Conceptos Relacionados
01:30Overview of Cell Death
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
01:30Apoptosis
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size reduction of the tissue.
01:24Caspases
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.
01:17The Extrinsic Apoptotic Pathway
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
01:31The Intrinsic Apoptotic Pathway
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
01:22Cellular Injury V: Apoptosis and Autophagy
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...