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Efecto de la privación del sueño en la secreción general de 24 horas de la hormona del crecimiento
Lancet (London, England)
|October 29, 2000
Resumen
La privación del sueño amortigua la liberación nocturna de la hormona del crecimiento (GH), pero la secreción diurna lo compensa. La secreción diaria total de GH sigue siendo similar, lo que sugiere que los trastornos del sueño no inhiben el crecimiento a través de la deficiencia de GH en los niños.
Área de la Ciencia:
- Endocrinología Endocrinología.
- Ciencia del sueño Ciencia del sueño Ciencia del sueño
- Crecimiento pediátrico.
Sus antecedentes:
- La privación del sueño afecta la regulación hormonal, en particular la secreción de la hormona del crecimiento (GH).
- El patrón diurno de liberación de GH se asocia principalmente con el inicio del sueño.
Objetivo del estudio:
- Para investigar el impacto de la privación aguda del sueño en la secreción de la hormona del crecimiento (GH) durante 24 horas.
- Para determinar si los embotados pulsos nocturnos de GH son compensados por la secreción diurna.
- Para abordar la hipótesis de que los trastornos del sueño inhiben el crecimiento a través de la deficiencia de GH.
Principales métodos:
- Utilizó un protocolo controlado de privación del sueño.
- Patrones de secreción de la hormona del crecimiento (GH) monitoreados las 24 horas.
- Comparación de los niveles de GH en individuos privados de sueño versus controles.
Principales resultados:
- La privación del sueño embotó el pulso normal de GH relacionado con el sueño.
- La secreción diurna de GH compensó significativamente el pulso nocturno embotado.
- La secreción total de GH durante 24 horas fue comparable entre los estados de privación y no privación de sueño.
Conclusiones:
- La privación aguda del sueño no conduce a un déficit diario neto en la secreción de GH.
- El cuerpo compensa la pérdida de la liberación de GH relacionada con el sueño.
- Es poco probable que los trastornos del sueño en los niños inhiban el crecimiento únicamente a través de un déficit diario de GH.
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