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Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
Efectos adversos del tratamiento antirretroviral
1HIV, Immunology and Infectious Diseases Clinical Services Unit, St Vincent's Hospital, Sydney, New South Wales, Australia. acarr@stvincents.com.au
Lancet (London, England)
|October 29, 2000
Resumen
La toxicidad de los medicamentos antirretrovirales es una preocupación creciente para los pacientes con VIH. Esta revisión detalla las causas, síntomas y tratamientos para los efectos adversos de 15 medicamentos antirretrovirales.
Área de la Ciencia:
- Enfermedades infecciosas Enfermedades infecciosas.
- Farmacología Farmacología.
- La medicina clínica es la medicina clínica.
Sus antecedentes:
- La infección por VIH se maneja cada vez más como una enfermedad crónica.
- El uso a largo plazo de múltiples medicamentos antirretrovirales es común.
- Las infecciones oportunistas en pacientes con VIH han disminuido significativamente.
Objetivo del estudio:
- Revisar la patogénesis, las características clínicas y el manejo de las toxicidades de los medicamentos antirretrovirales.
- Para cubrir las principales toxicidades asociadas con 15 medicamentos antirretrovirales con licencia.
- Discutir los efectos adversos específicos de la droga y el manejo en entornos clínicos especiales.
Principales métodos:
- Revisión de la literatura sobre las toxicidades de los medicamentos antirretrovirales.
- Análisis de la patogénesis y las manifestaciones clínicas.
- Síntesis de las estrategias de gestión actuales.
Principales resultados:
- Toxicidades clave identificadas, incluida la toxicidad mitocondrial, la hipersensibilidad y la lipodistrofia.
- Efectos adversos específicos de fármacos detallados para 15 agentes antirretrovirales.
- Destacó los desafíos en la gestión de las toxicidades en poblaciones específicas de pacientes.
Conclusiones:
- La toxicidad antirretroviral requiere un monitoreo y un manejo cuidadosos en la atención del VIH.
- La comprensión de los efectos adversos específicos de la droga es crucial para un tratamiento eficaz.
- Se justifica una mayor investigación para mitigar la toxicidad antirretroviral.
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