Video Experimental Relacionado

Updated: Jun 30, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

La activación del complejo de la kinasa IkappaB por TRAF6 requiere un complejo enzimático dimérico de conjugación de

L Deng1, C Wang, E Spencer

  • 1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas 75390, USA.

Cell
|November 1, 2000
PubMed
Resumen

El factor 6 asociado al receptor del factor de necrosis tumoral (TRAF6) activa la kinasa IkappaB (IKK) a través de las cadenas de poliubiquitina de la lisina-63 (K63). Esta nueva vía de señalización de la ubiquitina es crucial para la activación de NF-kappaB en respuesta a las citoquinas inflamatorias.

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