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Analyzing Large Protein Complexes by Structural Mass Spectrometry
15:35

Analyzing Large Protein Complexes by Structural Mass Spectrometry

Published on: June 20, 2010

Bases estructurales para la activación de los proteasomas 20S por los reguladores 11S

F G Whitby1, E I Masters, L Kramer

  • 1Biochemistry Department, University of Utah, Salt Lake City 84132, USA.

Nature
|November 18, 2000
PubMed
Resumen

El proteosoma 20S, crucial para la descomposición de las proteínas celulares, abre su puerta a través de los reguladores 11S (PA26). Este cambio estructural facilita la liberación del producto peptídico, lo que afecta a la producción de moléculas de la clase I del complejo de histocompatibilidad principal.

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