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El desarrollo temprano de las columnas de dominación ocular
1Howard Hughes Medical Institute and Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. jcrowley@neuro.duke.edu
Science (New York, N.Y.)
|November 18, 2000
Resumen
Las primeras columnas de dominación ocular en hurones se forman independientemente de la actividad de la retina. Esto sugiere mecanismos distintos para el desarrollo inicial de la columna frente al refinamiento dependiente de la actividad posterior en la corteza visual.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Neurociencia del desarrollo neurológico.
- Desarrollo de sistemas visuales Desarrollo de sistemas visuales
Sus antecedentes:
- Las columnas de dominación ocular (ODC) en la corteza visual son cruciales para la visión binocular.
- Tradicionalmente se cree que su formación depende de procesos prolongados y dependientes de la actividad.
- El desarrollo temprano y los mecanismos precisos de la formación de ODC siguen siendo incompletamente entendidos.
Objetivo del estudio:
- Investigar los mecanismos de formación temprana de las columnas de dominación ocular en la corteza visual del hurón.
- Determinar el papel de la actividad retiniana en la segregación inicial de los axones del núcleo geniculado lateral (LGN).
- Diferenciar entre los mecanismos de formación inicial de ODC y la plasticidad posterior dependiente de la actividad.
Principales métodos:
- Inyección directa de marcadores en el núcleo geniculado lateral (NGL) de los hurones posnatales tempranos.
- Visualización y análisis de la segregación y orientación de los axones LGN en la capa cortical 4.
- Inducir experimentalmente desequilibrios en la actividad de la retina para evaluar su impacto en la formación de la columna.
Principales resultados:
- Se observaron columnas de dominación ocular segregadas en el LGN menos de 7 días después de la inervación de la capa 4.
- Estas columnas de formación temprana eran resistentes a los desequilibrios inducidos experimentalmente en la actividad de la retina.
- Esto indica que la formación inicial de ODC es independiente de la actividad visual.
Conclusiones:
- La formación inicial de columnas de dominación ocular no se basa en la plasticidad dependiente de la actividad.
- Las poblaciones axonales distintas pueden apuntar a localizaciones específicas de la capa 4 para la segregación inicial.
- Mecanismos separados rigen el establecimiento inicial y el posterior refinamiento de los ODC durante el período crítico.
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