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Complejos inmunológicos circulantes en hombres de 50 años como un factor de riesgo fuerte e independiente para el
A Mustafa1, S Nityanand, L Berglund
1Immunological Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Circulation
|November 22, 2000
Resumen
Los complejos inmunes circulantes (CIC) y los autoanticuerpos de cardiolipina en hombres de 50 años predicen el riesgo futuro de infarto de miocardio (IM). Los CIC elevados solos o con anticuerpos indican un mayor riesgo, independientemente de otros factores.
Área de la Ciencia:
- Investigación de Enfermedades Cardiovasculares Investigación de Enfermedades Cardiovasculares
- Inmunología Inmunología.
- La medicina preventiva es la medicina preventiva de las enfermedades.
Sus antecedentes:
- La aterosclerosis y el infarto de miocardio (IM) están relacionados con los complejos inmunes circulantes (CIC) y los autoanticuerpos contra los LDL oxidados y la cardiolipina.
- El valor predictivo de estos biomarcadores para el riesgo de infarto de miocardio en individuos sanos no estaba claro anteriormente.
Objetivo del estudio:
- Investigar la capacidad predictiva de los CIC y los autoanticuerpos contra la cardiolipina para el infarto de miocardio (IM) en hombres sanos.
- Para determinar si estos marcadores pueden identificar a las personas con mayor riesgo de futuros eventos cardiovasculares.
Principales métodos:
- Un estudio prospectivo de casos y controles anidados siguió a 257 hombres sanos de 50 años durante 20 años.
- Los niveles medidos de CIC y los autoanticuerpos (IgG, IgM) contra la cardiolipina al inicio.
- La comparación de los niveles de biomarcadores entre los hombres que desarrollaron MI y los controles de la misma edad.
Principales resultados:
- Los hombres que desarrollaron MI tenían una mayor prevalencia y concentración de CIC que los controles sanos.
- Las concentraciones basales de CIC a los 50 años aumentaron significativamente el riesgo de infarto de miocardio, independientemente de otros factores de riesgo.
- CICs elevados correlacionados con anticuerpos IgG contra la cardiolipina; la presencia combinada indicó un mayor riesgo.
Conclusiones:
- Los complejos inmunológicos circulantes (CIC) a los 50 años predicen el riesgo de infarto de miocardio (IM) posterior hasta los 70 años.
- Los CIC, solos o con autoanticuerpos de cardiolipina, sirven como predictores significativos de infarto en hombres sanos.
- Estos hallazgos destacan los posibles biomarcadores para la evaluación temprana del riesgo cardiovascular.
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