Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
Sympathetic Signaling01:31

Sympathetic Signaling

Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
Sympathetic Activation01:16

Sympathetic Activation

The sympathetic division can influence tissues and organs by releasing norepinephrine at peripheral synapses and distributing epinephrine and norepinephrine through the bloodstream. In times of crisis or stress, sympathetic activation occurs, which is regulated by sympathetic centers in the hypothalamus. As a result, sympathetic activation prepares the body for physical exertion, rapid ATP production, and heightened alertness, allowing individuals to respond effectively to challenging or...
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

The impact of war on the development and progression of arterial hypertension and cardiovascular disease: protocol of a prospective study among Ukrainian female refugees.

Frontiers in cardiovascular medicine·2024
Same author

Blood product wastage reduction by utilising low-cost, low-impact multimodal physician-to-physician communication initiatives.

Transfusion medicine (Oxford, England)·2019
Same author

The phenomenon of HbA1c stability and the risk of hypoglycemia in long-standing type 1 diabetes.

Diabetes research and clinical practice·2019
Same author

Impatiens necrotic spot virus and Tomato spotted wilt virus Diagnosed in Phalaenopsis Orchids from Two Florida Nurseries.

Plant disease·2019
Same author

Wavelet transform analysis to assess oscillations in pial artery pulsation at the human cardiac frequency.

Microvascular research·2015
Same author

CrossTalk opposing view: Which technique for controlling resistant hypertension? Carotid chemoreceptor denervation/modulation.

The Journal of physiology·2014

Video Experimental Relacionado

Updated: May 12, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

La activación simpática por el sildenafil.

B G Phillips1, M Kato, C A Pesek

  • 1Division of Clinical and Administrative Pharmacy, Department of Internal Medicine, University of Iowa, Iowa City, USA.

Circulation
|January 11, 2000
PubMed
Resumen
Este resumen es generado por máquina.

Sildenafil aumenta significativamente la actividad del sistema nervioso simpático en reposo y durante el estrés. Esta mayor activación simpática puede estar relacionada con eventos cardiovasculares asociados con el uso de sildenafil.

Más Videos Relacionados

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Videos de Experimentos Relacionados

Last Updated: May 12, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
06:30

Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats

Published on: September 11, 2018

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Área de la Ciencia:

  • Fisiología cardiovascular fisiología cardiovascular.
  • Neurofarmacología y Neurofarmacología.

Sus antecedentes:

  • El citrato de sildenafilo es un tratamiento común para la disfunción eréctil.
  • Sus efectos sobre la circulación neural y las respuestas al estrés no se comprenden bien.

Objetivo del estudio:

  • Para investigar el impacto del sildenafil en el control neural de la circulación.
  • Para evaluar los efectos del sildenafil en las respuestas neurocirculadoras durante el estrés.

Principales métodos:

  • 14 voluntarios sanos recibieron 100 mg de sildenafilo o placebo en un estudio cruzado doble ciego.
  • Las mediciones incluyeron presión arterial, frecuencia cardíaca, resistencia vascular del antebrazo, actividad del nervio simpático muscular y catecolaminas plasmáticas.
  • Se evaluaron las respuestas a diversos factores estresantes físicos y mentales.

Principales resultados:

  • El sildenafilo aumentó notablemente la actividad nerviosa simpática muscular (141%) y los niveles plasmáticos de norepinefrina (31%) en comparación con el placebo.
  • El tráfico nervioso simpático durante el estrés fue de 2 a 8 veces mayor después del sildenafil.
  • Las medidas hemodinámicas como la presión arterial y la frecuencia cardíaca se mantuvieron similares entre los grupos.

Conclusiones:

  • El sildenafilo induce una activación significativa del sistema nervioso simpático.
  • Esta activación ocurre tanto en reposo como durante factores de estrés fisiológico.
  • Los hallazgos sugieren un mecanismo potencial para eventos cardiovasculares relacionados con el uso de sildenafil.